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http://cicese.repositorioinstitucional.mx/jspui/handle/1007/1655| Serum IL-12 is increased in mexican obese subjects and associated with low-grade inflammation and obesity-related parameters | |
| KARINA SUAREZ ALVAREZ | |
| LOURDES SOLIS_LOZANO SONIA ANDREA LEON CABRERA ANTONIO GONZALEZ Gregorio Maria Quiñones AURORA ELIZABETH SERRALDE ZUÑIGA JOSELIN HERNANDEZ RUIZ Jorge Ramírez Velásquez FRANCISCO GALINDO Julio Zavala MARCO ANTONIO DE LEON NAVA GUILLERMO BENITO ROBLES DIAZ Galileo Escobedo | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| http://dx.doi.org/10.1155/2013/967067 | |
| Obese Subjects, Obesity, IL-12, Alterations in humans, Clinical study | |
| "Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r = 0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r = 0.4481), body fat percentage (r = 0.5625), serum glucose (r = 0.3158), triglyceride (r = 0.3714), and TNF-α (r = 0.4717).Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesityassociated alterations in humans." | |
| Hindawi Publishing Corporation | |
| 2013 | |
| Artículo | |
| Mediators of Inflammation, Vol. 2013, Págs. 1-8 | |
| Inglés | |
| Suárez Álvarez,K.,Solís Lozano,L.,León Cabrera,S., González Chávez,A.,Gómez Hernández,G.,Quiñones Álvarez,M.S.,Serralde Zúñiga,A.E.,Hernández Ruíz,J.,Ramírez Velásquez,J.,Galindo González,F.J.,Zavala Castillo,J.C., De León Nava,M.A.,Robles Díaz,G.,Escobedo,G.2013.Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters.Mediators of Inflammation,2013(2013),1-8.doi:10.1155/2013/967067 | |
| CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos - Biotecnología Marina |
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