Please use this identifier to cite or link to this item: http://cicese.repositorioinstitucional.mx/jspui/handle/1007/1655
Serum IL-12 is increased in mexican obese subjects and associated with low-grade inflammation and obesity-related parameters
KARINA SUAREZ ALVAREZ
LOURDES SOLIS_LOZANO
SONIA ANDREA LEON CABRERA
ANTONIO GONZALEZ
Gregorio
Maria Quiñones
AURORA ELIZABETH SERRALDE ZUÑIGA
JOSELIN HERNANDEZ RUIZ
Jorge Ramírez Velásquez
FRANCISCO GALINDO
Julio Zavala
MARCO ANTONIO DE LEON NAVA
GUILLERMO BENITO ROBLES DIAZ
Galileo Escobedo
Acceso Abierto
Atribución-NoComercial-SinDerivadas
http://dx.doi.org/10.1155/2013/967067
Obese Subjects, Obesity, IL-12, Alterations in humans, Clinical study
"Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r = 0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r = 0.4481), body fat percentage (r = 0.5625), serum glucose (r = 0.3158), triglyceride (r = 0.3714), and TNF-α (r = 0.4717).Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesityassociated alterations in humans."
Hindawi Publishing Corporation
2013
Artículo
Mediators of Inflammation, Vol. 2013, Págs. 1-8
Inglés
Suárez Álvarez,K.,Solís Lozano,L.,León Cabrera,S., González Chávez,A.,Gómez Hernández,G.,Quiñones Álvarez,M.S.,Serralde Zúñiga,A.E.,Hernández Ruíz,J.,Ramírez Velásquez,J.,Galindo González,F.J.,Zavala Castillo,J.C., De León Nava,M.A.,Robles Díaz,G.,Escobedo,G.2013.Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters.Mediators of Inflammation,2013(2013),1-8.doi:10.1155/2013/967067
CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos - Biotecnología Marina

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