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Apoptosis activation in human lung cancer cell lines by a novel synthetic peptide derived from Conus californicus venom
IRASEMA OROZ PARRA
Mario Navarro
KARLA EVELIA CERVANTES LUEVANO
CAROLINA ALVAREZ DELGADO
Guy Salvesen
LILIANA NOEMI SANCHEZ CAMPOS
ALEXEI FEDOROVISH LICEA NAVARRO
Acceso Abierto
Atribución-NoComercial-SinDerivadas
http://dx.doi.org/10.3390/toxins8020038
Lung cancer, Synthetic peptide, Apoptotic-related genes, Caspase-3 and -7, Apoptosis, Pathway
"Lung cancer is one of the most common types of cancer in men and women and a leading cause of death worldwide resulting in more than one million deaths per year. The venom of marine snails Conus contains up to 200 pharmacologically active compounds that target several receptors in the cell membrane. Due to their diversity and specific binding properties, Conus toxins hold great potential as source of new drugs against cancer. We analyzed the cytotoxic effect of a 17-amino acid synthetic peptide (s-cal14.1a) that is based on a native toxin (cal14.1a) isolated from the sea snail Conus californicus. Cytotoxicity studies in four lung cancer cell lines were complemented with measurement of gene expression of apoptosis-related proteins Bcl-2, BAX and the pro-survival proteins NFκB-1 and COX-2, as well as quantification of caspase activity. Our results showed that H1299 and H1437 cell lines treated with s-call4.1a had decreased cell viability, activated caspases, and reduced expression of the pro-survival protein NFκB-1. To our knowledge, this is the first report describing activation of apoptosis in human lung cancer cell lines by s-cal14.1a and we offer insight into the possible mechanism of action."
MDPI AG
2016
Artículo
Toxins, Vol. 8, No. 2, Págs. 1-16
Inglés
Oroz Parra,I.,Navarro,M.,Cervantes Luevano,K.E.,Álvarez Delgado,C.,Salvesen,G.,Sánchez Campos,L.N.,Licea Navarro,A.F.2016.Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.Toxins,8(2),1-16.doi:10.3390/toxins8020038
BIOLOGÍA Y QUÍMICA
Versión publicada
publishedVersion - Versión publicada
Aparece en las colecciones: Artículos - Innovación Biomédica

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