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http://cicese.repositorioinstitucional.mx/jspui/handle/1007/1730| A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6 | |
| MARCO ANTONIO DE LEON NAVA | |
| CAROLINA ALVAREZ DELGADO LUIS DONIS MATURANO JOSELIN HERNANDEZ RUIZ Aarón Manjarrez-Reyna Edgar Cruz SONIA LEON-CABRERA JORGE MORALES MONTOR Fragoso Jose Manuel EUSTACIO GALILEO ESCOBEDO GONZALEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| http://dx.doi.org/10.1590/0074-02760160311 | |
| Acute liver failure, Acetaminophen, Parasite infection, Taenia crassiceps, Liver disease, Interleukin | |
| "We evaluated the effects of a non-hepatotropic parasite infection (Taenia crassiceps) on the outcome of acetaminophen-induced acute liver failure in mice. Uninfected and T. crassiceps infected mice orally received either 300 mg/kg acetaminophen or water as vehicle (n = 5 per group). Survival analysis, hepatocyte necrosis, alanine aminotransferase (ALT) levels, CYP2E1 protein, interleukin (IL-) 5, and IL-6 were assessed for all groups. All infected mice died within 16 h after exposure to acetaminophen (Tc+APAP group), whereas only one-third of uninfected animals exposed to acetaminophen (APAP group) died. Uninfected (Control group) and infected (Tc group) mice that received the vehicle showed no liver damage. Tc+APAP mice exhibited massive liver necrosis characterised by marked balloning degeneration of hepatocytes and higher serum ALT compared to Control, Tc, and APAP animals. Liver tissue from Tc+APAP mice also displayed increased expression of CYP2E1 protein and higher mRNA and protein levels of IL-5 and IL-6 compared to the other groups. These findings suggest that non-hepatotropic parasite infections may increase mortality following acute liver failure by promoting hepatocyte necrosis via IL-5 and IL-6-dependent CYP2E1 overproduction. This study identifies new potential risk factors associated with severe acute liver failure in patients." | |
| Instituto Oswaldo Cruz, Ministério da Saúde | |
| 2016 | |
| Artículo | |
| Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 12, Págs. 757-764 | |
| Inglés | |
| De León Nava,M.A.,Álvarez Delgado,C.,Donis Maturano,L.,Hernández Ruíz,J.,Manjarrez Reyna,A.N.,Cruz Avilés,E.,Leon Cabrera,S.,Morales Montor,J.,Fragoso,J.M.,Escobedo.G.2016.A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6.Memórias do Instituto Oswaldo Cruz,111(12),757-764.doi:10.1590/0074-02760160311 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos - Innovación Biomédica |
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