Please use this identifier to cite or link to this item: http://cicese.repositorioinstitucional.mx/jspui/handle/1007/1754
Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers
LETICIA RIVERON NEGRETE
Gloria Sicilia-Argumedo
CAROLINA ALVAREZ DELGADO
ELVIA COBALLASE URRUTIA
JONATHAN ALCANTAR FERNANDEZ
Cristina Fernandez_Mejia
Acceso Abierto
Atribución-NoComercial-SinDerivadas
http://dx.doi.org/10.1155/2016/7276463
Gene-Expression, Chromium Picolinate, Diabetes-Mellitus, Ampk Activation, Young-Rats, Glucose, Mice, Streptozotocin, Plasma, Deficiency
"Pharmacological concentrations of biotin have pleiotropic effects. Several reports have documented that biotin supplementation decreases hyperglycemia. We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion. We also found enlarged pancreatic islets and modified islet morphology. Other studies have shown that pharmacological concentrations of biotin modify tissue structure. Although biotin administration is considered safe, little attention has been given to its effect on tissue structure. In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers. Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks. Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts. Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes. In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes. Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers."
Hindawi Publishing Corporation
2016
Artículo
BioMed Research International, Vol. 2016, Págs. 1-9
Inglés
Riverón Negrete,L.,Sicilia Argumedo,G.,Álvarez Delgado,C.,Coballase Urrutia,E.,Alcántar Fernández,J.,Fernández Mejía,C.2016.Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers.BioMed Research International,2016,1-9.doi:10.1155/2016/7276463
BIOLOGÍA Y QUÍMICA
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos - Innovación Biomédica

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